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Phentermine is an appetite suppressant commonly used to for weight loss. Phentermine is in the same class as the powerful adrenaline-releasing drugs amphetamine and phenethylamine. Combined with consistent exercise, and a change in diet, obese patients with medical risks are prescribed Phentermine for fast and effective weight loss. Phentermine reduces chemicals in the brain responsible for appetite and reduce hunger. It also works outside of the brain by stimulating the use of fat cells for energy. It was approved by the Food and Drug Administration in 1959 and was marketed by many companies like Medeva and Gate under different names, although Medeva sells the name brand. Phentermine is best known in combination with fenfluramine and marketed as the now banned weight loss drug Fen-Phen. This drug was banned in 1997 when a large amount of people complained of heart valve disease.

In the brain, Phentermine release a neurotransmitter called norepinephrine that controls the fight-or-flight response in humans and reducing hunger. The fight-or-flight response causes an increase in heart rate, anxiety, and adrenaline. Most people report tolerating the drug well, but all drugs have certain side effects, mostly common and minor. Side effects are similar to these responses such as tachycardia (increased heart rate), elevated blood pressure, insomnia, hypertension, irritability, nervousness, euphoria, dry mouth, blurred vision, diarrhea, dizziness, stomach pain, palpitations, rash, and headache. Less common side effects include seizures, fever, hallucinations, hostility, tremors, panic, restlessness, and weakness. Phentermine, taken orally in tablet form, can last in the system for over 2 days and is excreted through the urine. It is classified as a controlled substance by the Food and Drug Administration and comes with a full list of precautions against people with existing thyroid, heart, valve, or blood pressure problems, history of substance abuse, pregnancy, or allergies. Also, people with diabetes, high cholesterol, a brain or spinal injury, or anyone taking any other herbal or dietary supplement are warned against using Phentermine.